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Mouzaki Karditsa is located at an altitude of 180 meters on the outskirts of Itamos. Crossed the stream Pamissos, ending in Penaeus. The inhabitants, about 4000, engaged in farming, agriculture, trade or work in public services.

In 1943, Mouzaki burned by Italian and therefore the houses are newly built, with few surviving examples of traditional architecture. The geographical position of the honors as a local commercial and administrative center. It is a crossroads and communications hub of the Karditsa Argithea, Epirus and the prefecture of Trikala. It is a point of reference for each resident, as the Flourishing his seat Argithea City, located 50 kilometers from Vragkiana, seat of the Municipality of Achelous, 75 km and 34 km from Petrilo, located east of the Community Argithea.

From Karditsa is 28 km. Linked to two country roads in the city of Trikala, which is 20 km, and Arta, which is 180 kilometers. Two roads starting in Planos, crossing the rugged area of ​​Argithea and reach the villages of the municipality Achelous and the prefecture of Arta: one crossing the Eastern Argithea and the second connects Thessaly to Epirus. This road is constantly being improved and road choice for many visitors to the prefecture of Karditsa, when weather conditions permit. The roads Kalambaka-Trikala-Planos-Lake Plastiras Pertouli-Gate-Planos-Lake Plastiras used by large numbers of visitors interested in ecotourism.

Long is the history of the region, as evidenced by the rich archaeological finds. Two kilometers northwest Mouzaki, in the "Diocese" placed the ancient city of molars, which controlled the entrances to the ancient Amvrakia, current Arta, and country of Athamanon (region Argithea). According to data from the archaeologists, the city founded in the 4th century BC, minted the first coin circa 340 BC and had a strong defensive wall. In 198 BC captured the Amynandros later Philip V of Macedonia in 48 BC Julius Caesar, the army whose looted. In the 6th century AD, the wall that surrounded restored by Justinian and the Byzantine period it became a bishop, which lasted until the Ottoman period.